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REVOLUTIONARY PHARMACEUTICAL
MIXERS AND PROCESSING EQUIPMENT

Pharmaceutical Mixing, Coating, Milling, and Reaction with ResonantAcoustic® Technology

Our customers include:

merck-logo
J&J-logo
amgen-logo
abbvie logo
lilly-logo
catalent-logo

Note: customer logos are registered trademarks for their respective organizations and do not constitute and endorsement.

Resonant Acoustic Mixing (RAM) technology is highly valuable in the pharmaceutical mixing industry due to its ability to mix powders, liquids, and semi-solids efficiently, precisely, and gently—without the drawbacks of traditional mixing methods. Here's a breakdown of why RAM is particularly useful in pharmaceutical applications:

  • Quality at speed — fast processing with superior homogeneity
  • Gentle processing — low shear, low heat
  • Multifunctional technology — mixing, dry powder coating, milling, granulation, chemical reaction
  • Bladeless — no blades or impellers, no cross-contamination
  • Low waste — easy to clean, less to throw away, environmentally friendly
  • Seamless scaleup — consistent results and recipes from lab to production
production mixing automation services

Pharmaceutical Mixer Testimonials

“…[We had] challenges with mixing a viscous (~10,000cp) solids-loaded cream consisting of water, excipient, API, and a sticky acrylate adhesive. It used to take multiple material addition steps and up to 8 hours with an overhead stirrer to achieve desired uniformity. With a LabRAM we performed the mix in a little more than 2 min…”
- U.S. biopharmaceuticals company

“...having these LabRAM II units has changed our processes in a positive manner. Every process involved with these units has become more stream-lined, and yield better and more consistent results.”
- Global pharmaceutical company

“We use these LabRAMs day in and day out, 18-20 hours a day…we run the heck out of them. We’re mixing several different powders in different quantities and no liquids. These [LabRAM] mixers do the trick.”
- U.S.-based neutraceuticals company

Resonant Acoustic Applications in the Pharmaceutical Industry

RAM is capable of much more than just mixing. ResonantAcoustic® technology is ideal for advanced material processing including pharmaceutical mixing, milling, coating, and chemical reaction. Here is a list of common use-cases where RAM shines above the rest:

Mixing Applications

  • API and Excipient Powders
  • Viscous gels
  • HTE/HTS
  • Liquid suspensions
  • Pharmaceutical compounding

Milling Applications

  • Nano milling
  • Ball/bead milling
  • Grinding
  • Deagglomeration
  • Solubility/Bioavailability

Coating Applications

  • Dry powder coating
  • Wet coating
  • Delayed release
  • Taste masking
  • Coating preparation

Reaction Applications

  • Green chemistry
  • Solvent reduction
  • Cocrystal formation
  • Mechanochemistry

RAM Compliance in the Pharmaceutical Industry

RAM is fully compliant with pharmaceutical standards, including cGMP, IQ/OQ/PQ, and FDA 21 CFR Part 11. Discuss your compliance needs with a sales engineer to understand the required specification to meet your needs.

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RAM CASE STUDIES IN PHARMACEUTICAL APPLICATIONS

How RAM Has Transformed Operations in Pharma Processing

VALIDATING RAM FOR PHARAMACEUTICAL MIXING AND PROCESSING

Pharmaceutical mixing eqiupment is critical. RAM is available for testing and validation through the following process:

  1. Demonstration
    A sales engineer will arrange an online demonstration via conference call to show you a lab scale version or
    RAM so you can see for yourself how it works. In some locations, we can offer in-person visits.
  2. Free material testing
    We can arrange a free mix, coating, milling, or reaction test with your material or a suitable surrogate. You
    send us the material, we process it, document it, and send it back to you for validation. Material SDS required,
    no hazardous materials accepted.
  3. Rental program
    We offer the LabRAM I for a monthly rental, with the first month’s rent applying to the cost of a purchase. Try
    RAM out in your lab and run as many tests as you would like.
  4. Quotation
    Once you have had time to evaluate RAM through either a demonstration, mix test, or rental, we will provide a
    quote that matches your application needs, however simple or complex they may be.
  5. Performance Testing
    After purchase, we can also perform validation and testing (FAT, SAT, etc) of your new machine per your
    requirements, including compliance, performance, quality, and safety tests prior to or post installation.
RAM 5 in Pharmaceutical Production
Customer performs Factory Acceptance Test (FAT) at Resodyn prior to shipping new RAM5 automated system for pharmaceutical manufacturing in a custom vessel.

Patents Featuring RAM Technology

Seal of the United States Patent and Trademark Office

Many of our customers discover that RAM mixing, milling, coating, and chemical reaction technology is so powerful, they apply for US and International patents to protect their process design and newfound competitive edge.

Key examples include:

Research Featuring RAM Technology

Complete Cocrystal Formation during Resonant Acoustic Wet Granulation: Effect of Granulation Liquids

Applying Dry Powder Coatings

A novel method for preparing stabilized amorphous solid dispersion drug formulations using acoustic fusion

Influence of guest and host particle sizes on dry coating effectiveness: When not to use high mixing intensity

Impact of Method of Preparation of Amorphous Solid Dispersions on Mechanical Properties: Comparison of Coprecipitation and Spray Drying

Ball-free mechanochemistry: in situ real-time monitoring of pharmaceutical co-crystal formation by resonant acoustic mixing

Influence of Material Properties on the Effectiveness of Glidants Used to Improve the Flowability of Cohesive Pharmaceutical Powders

Mapping the dark space of chemical reactions with extended nanomole synthesis and MALDI-TOF MS

High-throughput screening and scale-up of cocrystals using resonant acoustic mixing

Effect of resonant acoustic mixing on pharmaceutical powder blends and tablets

Verification of the mixing processes of the active pharmaceutical ingredient, excipient and lubricant in a pharmaceutical formulation using a resonant acoustic mixing technology

Characterization of resonant acoustic mixing using near-infrared chemical imaging

In-line and Real-time Monitoring of Resonant Acoustic Mixing by Near-infrared Spectroscopy Combined with Chemometric Technology for Process Analytical Technology Applications in Pharmaceutical Powder Blending Systems

Evaluation of resonant acoustic mixing performance

High-Throughput Tools for Optimizing Drug Nanosuspensions

Development and Scale-Up of Cocrystals Using Resonant Acoustic Mixing

A new and improved method for the preparation of drug nanosuspension formulations using acoustic mixing technology

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